ABSTRACT The modulatory neurotransmitter norepinephrine and activation of -adrenergic receptors ( -ARs) has a crucial role in hippocampus-dependent forms of learning. Although β …

Genetic and biased agonist-mediated reductions in β-arrestin recruitment prolong cAMP signaling at glucagon family receptors Received for publication, October 9, 2020, and in revised form, …

Receptor-binding studies have demonstrated that labetalol interacts with alpha- and beta-adrenocep-tors. Drug displacement studies indicate that the affinity of labetalol is about 10 …

Abstract The TGF- β type V receptor (TβR- V) mediates growth inhibition by IGFBP- 3 and TGF- β in epithelial cells and loss of TβR- V expression in these cells leads to de-velopment of …

Madrigal’s lead product candidate is resmetirom, a thyroid hormone receptor In Phase 2 and Phase 3 studies, patients treated with resmetirom showed improvements in key measures of …

Myosin light chain phosphatase is a downstream target of Rho-kinase in endothelin-1-induced transactivation of the TGF-β receptor Maryam Rezaei1 Jawahar Lal Mehta2