近日，北京大学药学院马明团队在 JACS 上发表了题为 “Structural Insights into Three Sesquiterpene Synthases for the Biosynthesis of Tricyclic Sesquiterpenes and Chemical Space Expansion by Structure-Based Mutagenesis” 的研究论文。

Natural molecular evolution has created enzymes designed to catalyse a single reaction, by modifying enzymes that were once much less choosy. Yoshikuni et al. have developed a method of designing ...

Yin, Aureane-type sesquiterpene tetraketides as a novel class of immunomodulators with interleukin-17A inhibitory activity, Acta Pharmaceutica Sinica B, Volume 13, Issue 9, 2023, Pages 3930-3944, ...

An important compound in this context is merrillianin, a type of illicium sesquiterpene that was isolated in 2002 from the fruit of Illicium merrillianum, a plant that belongs to the same genus as ...

As Dada explains, “This can be explained by the fact that a sesquiterpene molecule consists of 15 carbon atoms, while monoterpenes consist of only 10 and isoprenes only five.” With its higher ...

The sesquiterpene that researchers have studied most is lactucin, which is also present in common lettuce and chicory. According to the review, ...