研究人员将直接转分化获得的人肝细胞hiHeps自组装形成肝脏类器官，并向其中分别引入可致HCC（hepatocellular carcinomas，肝细胞癌）的c-Myc基因和可致ICC（intrahepatic cholangiocarcinomas，肝内胆管细胞癌）的RAS基因，在体外分别模拟人类HCC和ICC的发生，探索潜在的早期预防和治疗策略。

Intrahepatic cholangiocarcinomas occur mostly in the normal liver but they also arise in chronic advanced liver diseases. However, genetic differences between two groups have yet to be examined.

Intrahepatic cholangiocarcinomas were classified into two types based on their microscopic appearance. Tumors with histologic similarities to hilar cholangiocarcinomas (predominantly ductal ...

Conclusions: Five-year survival rates for cholangiocarcinomas are low. To improve outcomes, improved early detection methods and better treatment options are urgently needed. Increasing the frequency ...

Cholangiocarcinomas are malignant tumors that derive from cholangiocytes of small intrahepatic bile ducts or bile ductules (intrahepatic cholangiocarcinoma; ICC), or of large hilar or extrahepatic ...

Cholangiocarcinomas are tumors that arise in the bile ducts — tubes connecting the liver to the small intestine that carry bile, a fluid that helps digest fats and excrete wastes. Diagnosed in over ...

Cholangiocarcinomas that occur in the small bile ducts within the liver are termed “intrahepatic.” Those that arise in the bile ducts but outside the liver are “extrahepatic.” In some cases, these ...

Grossly, the liver involved by cholangiocarcinoma is usually enlarged, partly because of the tumor itself and partly because of hydrohepatosis (enlargement of the liver due to fluid retention ...

The purpose of this phase II trial was to evaluate the efficacy of chemotherapy and the EGFR-inhibitor panitumumab in KRAS wt cholangiocarcinomas. Methods: Main eligibility criteria were performance ...

Distal cholangiocarcinomas are rare, but clinicians can use a variety of imaging to diagnose it. A new case report of a patient with distal cholangiocarcinoma highlights how imaging and ...

The progenitor cell marker Nestin may be a meaningful diagnostic tool for combined hepatocellular-cholangiocarcinoma (cHCC-CCA) and may help identify a subset of patients with a poor prognosis ...