BACKGROUND: Direct reprogramming of fibroblasts to cardiomyocytes is a potentially curative strategy for ischemic heart ...

Direct reprogramming enables the generation of pluripotent stem-cell lines from almost any somatic tissue and mammalian species, thereby avoiding the ethical issues associated with human embryonic ...

SeamlessTx is addressing this challenge with a unique platform that integrates large-scale directed evolution and machine learning (ML)-driven models to predict recombinase variant activity and ...

This partial reprogramming extended the mice’ lifespan from 18 weeks to 24 on average. The mice looked visibly younger, their organ function improved, and importantly, they did not develop tumors. To ...

Reprogramming the Genome New Center for Physical Genomics and Engineering ignites a revolution in medical research and beyond. Emily Ayshford. The Center for Physical Genomics and Engineering focuses ...

One promising strategy to remuscularize the injured heart is the direct cardiac reprogramming of heart fibroblast cells into cardiomyocytes. Researchers have identified TBX20 as the key missing ...

The ability to create stem cells from non-embryonic cells, through the process of reprogramming, lifted the ethical hindrance and is driving stem cell research in a new direction at a rapid pace. A ...

Hao Huang from Mass's lab. "And this happened even when the young animals were fed a completely normal diet." The cause of this disorder seems to be a kind of "reprogramming" of the Kupffer cells in ...

A new way of reprogramming our immune cells to shrink or kill off cancer cells has been shown to work in the otherwise hard to treat and devastating skin cancer, melanoma. The discovery ...

In a study published in the prestigious journal Nature Cancer, researchers led by Professor Cédric Blanpain, MD/PhD, WELBIO researcher, director of the Stem Cells and Cancer Laboratory, and professor ...