The polybasic region forms an electrostatic interaction with the negatively charged headgroups of the inner leaflet of the plasma membrane.

A computer model showing the polybasic cleavage sites, located on the novel coronavirus' protein spike.

Made up of amino acids, SARS-CoV-2's polybasic cleavage sites have remained elusive since the COVID-19 outbreak began. But previous research indicates that these mysterious sites are essential for ...

The COVID-19 virus causing the pandemic evolved from naturally occurring strains, according to a new comparative genomic analysis.

Furthermore, upon comparing sequences of the S1/S2 genomic region, remains of a polybasic FCS motif at the S1/S2 boundary in 12 of the 17 CoVs from Europe, Asia, and Africa were seen.

Researchers evaluated the importance of the P681 residue within the furin cleavage site of SARS-CoV-2 spike protein in determining the fusogenicity and syncytia formation ability of SARS-CoV-2 ...